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In Rome he also started working in the circle of Michelangelo and befriended him. Michelangelo used his influence with Pope Paul III to secure Daniele commissions and the post of superintendent of the works of the Vatican, a position he retained until the Pope's death. Michelangelo provided him with sketches on which Daniele based some of his paintings, especially his series of frescoes in the Orsini chapel in the Trinità dei Monti, the commission for which Daniele had received in December of 1541.
Later Daniele was commissioned by Paul III to complete the decoration of the Sala Regia. On the death of the pope in 1549 he lost his position as superintendent and the pension to which it entitled him. He then devoted himself chiefly to sculpture.He died in Rome, 1566. According to Daniele's will, the marble knee of the missing left leg of the Christ from Michelangelo's Deposition was in his possession at the time of his death.
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